Glimepiride is indicated as an adjunct to diet and exercise to lower the blood glucose in patients with noninsulin-dependent (Type II) diabetes mellitus (NIDDM) whose hyperglycemia cannot be controlled by diet and exercise alone. Glimepiride may be used concomitantly with metformin when diet, exercise, and Glimepiride or metformin alone do not result in adequate glycemic control. Glimepiride is also indicated for use in combination with insulin to lower blood glucose in patients whose hyperglycemia cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic agent. Combined use of Glimepiride and insulin may increase the potential for hypoglycemia.
"We are pleased to receive this tentative approval for Glimepiride Tablets. This product represents an interesting opportunity for Ranbaxy in which we will offer six strengths of this oral hypoglycemic agent to support dosing flexibility that will be of benefit to both prescribers and patients. Glimepiride Tablets, 1, 2 and 4 mg strengths are available through the innovator company. RPI will offer these tablet strengths, as well as 3, 6, and 8 mg that are additional strengths developed through Ranbaxy's R&D organization. Product will be launched following final approval from the FDA on October 6, 2005," according to Jim Meehan, Vice President of Sales and Marketing for RPI.
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"There's no reason to believe that this is the only compound in broccoli that has an anti-cancer effect," said Steven Clinton, a study co-author and an associate professor of hematology and oncology at Ohio State. "There are at least a dozen interesting compounds in the vegetable.
"We're now studying more of those compounds to determine if they work together or independently, and what kind of effects they have on cancer cells," he added.
Broccoli isn't the only cruciferous veggie with health benefits, the researchers say. The plant's kin, which include cabbage, cauliflower, Brussels sprouts and kale, may all contain similar disease-fighting phytochemicals.
It's too early to suggest just how much broccoli or other cruciferous vegetables should be eaten to stave off or slow down the progression of bladder cancer. Still, they are an important part of the diet.
"Cruciferous veggies have an effect on other types of cancer, too," Schwartz said. "We already know that they contain compounds that help detoxify carcinogens. We're thinking more along the lines of progression and proliferation, such as once cancer starts, is there a way to slow it down?"
He and Clinton conducted the study with Ohio State colleagues Robin Rosselot, a graduate student in food science and technology and Qingguo Tian, a research associate also in food science and technology.
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