Cryolypolysis Freezes Fat Cells to Dissolve ThemAnother promising new fat removal technology, cryolypolysis uses an innovative approach of freezing fat cells in order to dissolve them. Dr. Dover explained that since fat cells are more sensitive to cold temperatures than other skin cells, they can be altered more easily when targeted with cold rather than with heat. Currently approved by the FDA for chilling the skin, cryolypolysis is not yet approved for body contouring, body shaping or fat reduction.

Cryolypolysis works by freezing the fat beneath the skin, which causes selective crystallization of lipids in fat cells that slowly dissolve without injuring any surrounding tissues. Since fat cell death occurs gradually, there is no trauma or immediate "bursting" of fat cells that can be caused by methods that use heat to destroy fat cells. For this reason, results are not immediate and fat layer reduction becomes visible gradually over the course of two to six months. In the first human study that used cryolypolysis to treat 32 subjects with love handles, Dr. Dover (the study's lead investigator) treated love handles on one side of the body with cryolypolysis and used the love handles on the opposite side of the body as the control. Four months after the procedure, the majority of subjects experienced a noticeable change in fat reduction in the treated love handle. In addition, Dr. Dover explained that ultrasound measurements taken on 10 of the 32 subjects showed an average fat layer reduction of 22.4 percent in all of these subjects four months after the procedure."Based on our early findings, cryolypolysis is a very exciting new approach for the non-invasive removal of localized fat in the belly, love handles, back and saddle bags of the thighs," said Dr. Dover. "Although this technology is still being developed, I think with further clinical testing cryolypolysis eventually could be expanded for use in other areas prone to excess fat, such as the neck, knees and arms."As mentioned, results in fat layer reduction with cryolypolysis are not immediate. Side effects are limited to slight discomfort, numbness and redness for an hour or two post-treatment, as well as some change in skin sensation in the treated area for up to two to three weeks.Dr. Dover further explained that for all of the non-invasive technologies studied to date, the research has not shown that the body's blood lipid profile changed after any of the treatments. "This finding is important, as it suggests that these procedures are safe," said Dr. Dover. "While we're not sure where the dissolved fat goes once it is dissolved, we think it gently goes into the bloodstream and that the body is able to absorb and process it in the liver."Given the recent expansion of clinical research designed to fine tune these non-invasive fat removal technologies and strong consumer interest in procedures that require little downtime, Dr. Dover estimates that this market will expand and consumer options will increase in the next five years.

Source: American Academy of Dermatology