Professor Claudine Junien from the Institut National de Recherche Agronomique (INRA) in France says: "For me a gene, a cell and even a sex does not think and has no intelligent design. Instead it reacts to diverse environments and situations according to what its build-up can afford, pushing in one direction or another (or several at a time). The limits to which it can go without going awry or dying have been established progressively throughout the slow and long process of evolution, with different genetic backgrounds throughout the world depending on the diversity of experiences over the ages. We have data showing that gene expression and DNA methylation are sexually dimorphic in male and female placentae under normal/control conditions. Surprisingly, in stressful conditions, such as a high fat diet or low calorie diet, or maternal overweight/obesity - the male and female placentae do not use the same strategies: they use different gene pathways and networks to cope with the stress. Does this directly lead to different outcomes? It may lead to sex-dependent differences in the outcome of programming with long lasting effects. Alternatively, it may be that metaphorically speaking males climb the mountain taking the north face while females take the south face - but they ultimately reach the same peak after using these different paths."

Professor Ricardo Closa Monasterolo from the University Rovira I Virgili of Tarragona, Italy, presents work that suggested that infant boys and girls might have different responses to lower or higher protein diets. Females given higher protein formula milk had higher IGF-1 levels than males, whilst males showed higher C-peptide/creatinine levels compared to females. The significance of lower or higher protein diets has also been examined in the EU Childhood Obesity Project (CHOP) co-ordinated by Professor Berthold Koletzko of Ludwig-Maximilians-Universit?¤t (LMU) in Munich. Starting in 1990, over 1,000 infants were followed.

The first results show that, after 2 years, the infants fed a formula milk with a lower protein content - closer to the composition of breast milk - weighed significantly less than those on higher protein formula, with their weights being more similar to those of breast fed infants. These differences emerged by 6 months of age and persisted, even after the intervention ceased and the children went onto similar diets. The researchers predict that these low protein induced differences in early growth would reduce obesity at 14 to 16 years of age by 13%. Koletzko, who is also the Co-ordinator of the EARNEST project said, "This is a new and exciting area of research which suggests that some of the differences in disease risk seen in men and women in later life might be explained by different responses to programming effects in early life."

Source: University of Edinburgh