Although there are many causes for this disease, UGR scientists focused on smooth muscle cells (SMCs) transformation into dedifferentiated and proliferative cells, able to carry lipids in culture. In this sense, cells from animals fed with control diet represent a difference. Experts carried out an early cell atherosclerosis experimental model with chickens, as these birds develop atherosclerosis very rapidly: a 20-day high cholesterol diet is enough to detect atheromatous plaques in their arteries.
Experts obtained SMCs from arteries before the formation of the plaques. Ten days after the start of the high cholesterol diet , when atheromatous plaques are not still visible using an electron microscopic , aortic SMCs are extracted and in-vitro cultured. Experts cultured SMC-Cs (obtained from animals without a cholesterol dietary supplement) and SMC-Chs (extracted from animals with cholesterol dietary supplement) under the same conditions. After genetic analysis, scientists confirmed that regarding the samples (without cholesterol) modifications took place in birds fed with a high cholesterol diet. Differences show that cholesterol causes changes in messenger RNA synthesis in proteins related to lipid metabolism control, proliferation and apoptosis (programmed cell death) and, therefore, that diet has an influence on gene expression.
Through other studies, these experts discovered that, whilst cholesterol causes changes in gene expression, fish oil reverts such changes. In this case, scientists fed the animals with a high cholesterol diet for ten days, then substituted cholesterol for fish oil (rich in omega-3 and omega-6 polyunsaturated fatty acids) for another ten days.
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A 2005 National Cancer Institute study found that breast cancer patients in the study who reduced their fat consumption lowered their risk of tumor recurrence by as much as 42 percent. High-fat foods, including beef, vegetable oils, and chicken, can boost the hormones that promote cancer cell growth. But most plant-based foods are naturally low fat and offer people a healthy way to stay slim. Maintaining a healthy weight is another key to preventing cancer recurrence.
In 1982, the National Research Council linked eating habits-particularly high-fat, meat-heavy diets-to cancer of the breast and other organs. The "Journal of the National Cancer Institute" recently reported that the rate of breast cancer among premenopausal women who ate the most animal (but not vegetable) fat was a third higher than that of women who ate the least animal fat.
The Cancer Project is a collaborative effort of physicians, researchers, and nutritionists who have joined together to educate the public about the benefits of a healthy diet for cancer prevention and survival. Based in Washington, D.C., The Cancer Project is an affiliate of the Physicians Committee for Responsible Medicine.
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